There are three huge collections housed within this grand building: the Collection of Classical Antiquities, the Museum of Near Eastern Antiquities and the Museum of Islamic Art. The Pergamon Museum was the last museum built on Museumsinsel (Museum Island) and was intended to house the great acquisitions brought to Germany by archaeologists of the eighteenth and nineteenth century. The museum's best-known attraction is the Pergamonsaal. The Pergamon Altar (165 BC), from the eponymous Asia Minor city-state, is three stories high and served as the entrance gate to an entire complex. It is astounding both because of its size and extremely precise detail, especially in a frieze which shows the gods battling giants. The entire room is the same colour as the building's stone, making the details on the frieze section stand out even more. Facing the stairs, on the left hand side of the room there is a small-scale model of the altar which allows the viewer to see where the frieze segments would have been mounted. A 1:300 scale model of Pergamon city is on the right side of the room. The monumental market door of Milet has just been restored.Every first Sunday of the month, many museums in Berlin are free of charge. Sometimes a reservation is necessary in advance. For more information, see Museums Sonntag Booking.Since 2018 there is also a huge 360° panorama of Pergamon in another museum building, which is included in the Pergamon-only ticket.

The Pergamon Museum (German: Pergamonmuseum; pronounced [ˈpɛʁ.ɡa.mɔn.muˌzeː.ʊm] ) is a listed building on the Museum Island in the historic centre of Berlin, Germany. It was built from 1910 to 1930 by order of Emperor Wilhelm II and according to plans by Alfred Messel and Ludwig Hoffmann in Stripped Classicism style. As part of the Museum Island complex, the Pergamon Museum was added to the UNESCO World Heritage List in 1999 because of its architecture and testimony to the evolution of museums as architectural and social phenomena.

Prior to its closing in 2023, the Pergamon Museum was home to the Antikensammlung, including the famous Pergamon Altar, the Vorderasiatisches Museum and the Museum für Islamische Kunst.

In October 2023, the museum was completely closed for visitors, and is expected to remain mostly closed for 14 to 20 years – until 2037 to 2043 – for the execution of comprehensive renovation works. Its North Wing is expected to reopen in 2027.