The original mosque was built between 1463-1470 by the Greek architect Atik Sinan, by order of Sultan Mehmet II the Conqueror, on the site of the former Church of the Holy Apostles, which had served as Byzantine Imperial burial place for a thousand years. The grand complex with eight medreses, a library, hospital, hospice, caravanserai, market, hamam, primary school and public soup kitchen was smashed again and again by earthquakes, and the present building is from 1771 to a different design. The interior is lavish, and outside is the ornate tomb of Mehmet II and his wife Gülbahar Hatun.

The Fatih Mosque (Turkish: Fatih Camii, lit. 'The Conqueror's mosque'; Ottoman Turkish: فاتح جامع) is an Ottoman mosque off Fevzi Paşa Caddesi in the Fatih district of Istanbul, Turkey. The original mosque was constructed between 1463 and 1470 on the site of the Church of the Holy Apostles. Seriously damaged in the 1766 earthquake, it was rebuilt in 1771 to a different design. It is named after the Ottoman sultan Mehmed the Conqueror, known in Turkish as Fatih Sultan Mehmed, who conquered Constantinople in 1453.

The Sahn-ı Seman Medrese, once an important center for the study of theology, law, medicine, astronomy, physics and mathematics, formed part of the Fatih Mosque. It was founded by the Turkic astronomer Ali Qushji who had been invited by Mehmed to his court in Istanbul.

The mosque complex was completely restored in 2009 and again ten years later. It reopened to worshippers in 2021.