The Minor Basilica of Our Lady of the Pillar, also known as the Archdiocesan Shrine of the Blessed Sacrament or simply Santa Cruz Parish, is a Roman Catholic minor basilica in the district of Santa Cruz, Manila, Philippines. It is under the jurisdiction of the Archdiocese of Manila. The church was built when the arrabal (suburb) of Santa Cruz was established by the Jesuits in the early 17th century. The church had undergone many repairs and reconstruction, with the last reconstruction done in the 1950s.

It is the first mission and motherhouse of Filipino Sacramentinos, making it as the center of the congregation’s activities and events. Every year, the shrine hosts the archdiocesan celebrations of the Feast of Corpus Christi in the Archdiocese of Manila. A Mass is said by the Archbishop of Manila at 3:15 p.m., followed by a procession of the Blessed Sacrament to the Manila Cathedral.