Not, as commonly believed, named after the country but after the city of Strasbourg (Argentoratum in Latin), from which came a courtesan of Pope Alexander VI who lived nearby. Four Roman Republican-era temples, Pompey's theater and a Roman public toilet ("Latrina") have been excavated. The Pompey Theater is the site where Julius Caesar was stabbed to death by senators in 44 BC. The largo is also home to a large number of cats which are tended by the local animal rights organization - purportedly a jab at Mussolini who excavated the area and is said to have hated cats. As of September 2024 no cats could be seen at least from the street.

Largo di Torre Argentina (lit. 'Silver Tower Square', Italian: [ˈlarɡo di ˈtorre ardʒenˈtiːna]) is a large open space in Rome, Italy, with four Roman Republican temples and the remains of Pompey's Theatre. It is in the ancient Campus Martius. This was one of the places that the ancient "Argentario"—the silver/money men, the bankers—used to conduct their trade.

The name of the square comes from the Torre Argentina (Silver Tower), which takes its name from the city of Strasbourg whose Latin name was Argentoratum—Silver [city]. In 1503, the Papal Master of Ceremonies Johannes Burckardt, who came from Strasbourg and was known as "Argentinus", built in via del Sudario a palace (now at number 44), called Casa del Burcardo, to which the tower is annexed.

Julius Caesar was assassinated in the Curia of Pompey, and the spot where he is believed to have been assassinated is in the square.

After Italian unification, it was decided to reconstruct part of Rome (1909), demolishing the zone of Torre Argentina. However, during the demolition work in 1927, the colossal head and arms of a marble statue were discovered. The archaeological investigation brought to light the presence of a holy area, dating to the Republican era, with four temples and part of Pompey's Theatre.