No records of the exact date of construction exist but a solid brick structure was built on this site in 1622 and repaied in 1743. The cathedral has some impressive stained glass murals and the facade is characterised by its twin belfries. The exterior is clad in Shanghai plaster which gives the church a subdued appearance.

The Cathedral of the Nativity of Our Lady also Sé Catedral da Natividade de Nossa Senhora and Igreja da Sé (Chinese: 澳門主教座堂) is a Roman Catholic cathedral in Sé, Macau. It is the current cathedral of the Diocese of Macau. The cathedral is also called the "Church of the Nativity of Our Lady".

The cathedral is included in the list of historical monuments of the Historic Centre of Macau, which in turn is included in the list of World Heritage Sites in China.