Bounded by the Manila Cathedral to the southeast, the Palacio del Gobernador to the southwest and the Ayuntamiento to the northeast, this small plot of land is Intramuros' very own plaza mayor (main square). At the centre of the plaza stands a monument to King Carlos IV of Spain, cast in 1808 and erected in 1824 by a colonial government grateful for his having dispatched a shipment of smallpox vaccine to the Philippines.

Plaza de Roma, also known as Plaza Roma, is one of three major public squares in Intramuros, Manila. It is bounded by Andres Soriano Avenue to the north, Cabildo Street to the east, Santo Tomas Street to the south, and General Antonio Luna Street to the west. The plaza is considered to be the center of Intramuros. Plaza de Roma is also the location of the Book Stop Intramuros, a local unit of The Book Stop Project.